Acidic fibroblast growth factor enhances regeneration of processes by postnatal mammalian retinal ganglion cells in culture.
نویسندگان
چکیده
منابع مشابه
Basic, not acidic fibroblast growth factor stimulates proliferation of cultured human retinal pigment epithelial cells.
PURPOSE In this study, we evaluated a possible effect of acidic and basic fibroblast growth factor (aFGF, bFGF) on the proliferation of human retinal pigment epithelial (RPE) cells in culture. As the RPE is the primary source for bFGF in the retina, such an effect would suggest autocrinic actions of FGFs. METHODS Primary cultures of human and porcine RPE and an established human RPE cell line...
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Basic fibroblast growth factor (bFGF) was radiolabeled and used in axonal transport studies to determine whether certain neuronal populations express functional receptors for bFGF. Unlike 125I-NGF, 125I-bFGF was not retrogradely transported in the adult rat sciatic nerve or from iris to trigeminal ganglion or superior cervical ganglion. However, after intraocular injection of 125I-bFGF into the...
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Identified retinal ganglion cells were isolated from postnatal cat retinas and their dendrites were removed by trituration and centrifugation. The denuded cells were placed in a cell culture system and allowed to reexpress dendritic arbors in the absence of afferent input, target tissue, and interactions with neighboring ganglion cells. The retinal ganglion cells were grown above a feeder layer...
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During the first 2 postnatal weeks, up to 50% of the ganglion cells in the mammalian retina normally die. Natural cell death may result from several factors, and electrical activity has been proposed as one critical element. Recent experiments in vivo using intraocular injection of tetrodotoxin (TTX) have suggested that competition for survival between ganglion cells from the two eyes is mediat...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1988
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.85.7.2388